Active ingredients in insectoacaricidal preparations. Insectoacaricidal agent

Insectoacaricidal preparations are drugs of chemical or biological origin intended to combat harmful insects and ticks.

Therefore, it is important to know that the choice of safe and effective insectoacaricidal drugs is the key to the health of our little brothers. Based on the above, we will try in this article to help you with this choice.

Insectoacaricidal preparations can be characterized by the following characteristics:

1. Method of action.

1. Repellent properties.

There are repellents contactless And contact, when the insect needs direct contact with the animal's fur or skin for the product to work. Unfortunately, there are no contactless repellents that can protect a dog from tick attacks. The most effective contact repellents are: permerin, amitraz, flumethrin.

1. Resistance.

Resistance in our case is the ability of insects to be resistant to the effects of insectoacaricidal agents on them.

1. Efficiency.

Active ingredients in insectoacaricidal preparations

Now let’s take a closer look at the main active ingredients of insectoacaricidal drugs that are found on our market and are also available for sale in our pharmacy.

1.Phenylpyrazoles.

Fipronil and pyriprole are used in insectoacaricidal preparations. Fipronil is one of the most low-toxic and safe drugs. Piriprol was developed specifically for dogs and is more water resistant than fipronil. Substances of this group can cause hyperactivity of the animal and redness of the skin when applied. Possess high efficiency against ticks and fleas, they act by contact, accumulating in the sebaceous glands of the animal and practically not entering the blood. Resistance in ticks and fleas is unlikely. They do not have repellent properties. They act on ixodid mites, scabies mites, fleas, lice, and lice.

This group includes permethrin, flumethrin, phenothrin, deltamethrin, cyphenothrin, cypermethrin. Pyrethroid smokes are slightly toxic, but can cause skin reactions at the sites of application. The likelihood of resistance is high for fleas and ticks. The mode of action is contact, contact-intestinal, repellent properties are well expressed. The advantage of this group is that they accumulate in the sebaceous glands and are practically not absorbed into the animal’s bloodstream. These substances have a wide range of effects: fleas, ixodid and scabies mites, lice, mosquitoes and flies. Permethrintoxic to cats! In this regard, it is not recommended to use medications with this substance for your dog if you have a cat in your home.

Pyrethroids are contained in:

• A two-component drug that, in addition to pyrethroidflumethrin, contains imidocloprid, which works against fleas. The collar lasts eight months, is odorless, waterproof and, according to the manufacturer, can be used as primary protection. Manufacturer Bayer, Germany.
• Kiltix collar for dogs. Combines flumethrin and propoxur. Valid for six months. You can combine it with drops or sprays based on fipronil. Manufacturer Bayer, Germany.
• FrontlineTriAct drops for dogs. New from Merial. The combination of fipronil and permethrin increases the effectiveness of protection. The drops have a wide spectrum of action, and permethrin additionally gives them repellent properties. The drops are waterproof. Manufacturer Merial, France.
• Advantix drops for dogs. Imidocloprid, which is effective against fleas, has been added to permethrin. It is not recommended to wash or bathe your dog for seven days after treatment with the drug. As additional protection treatment with fipronil-based sprays can be added to the drops. Manufacturer Bayer, Germany.
• Vectra Drops 3Dfor dogs. In addition to permethrin, they contain dinotefuran (an agent that works against bedbugs) and pyriproxyfen. Pyriproxyfen is a juvenile hormone that disrupts the development of flea larvae. Manufacturer SEVA, France.
• DropsHartzUltraGuard. Contains phenothrin. The manufacturer claims that the drug is water resistant. Manufacturer Hartz, USA.
• Delcid solution. Contains deltamethrin. Can be used both for external treatment of animal hair, and for treatment of premises, enclosures, adjacent areas, etc. Manufacturer: Agrovetzashchita, Russian Federation.

1. Isoxazolines.

These include fluralaner and afoxolaner. Contained in tablets. The toxicity of the drugs is low. Efficiency is high. Mode of action – systemic, intestinal. There is currently no information about resistance, and the mechanism of action of the substance itself reduces the possibility of resistance to a minimum. They do not have repellent properties. They act against fleas, ixodid and demodectic ticks. Suitable for all breeds of dogs. Repeated bathing and shampooing do not affect the effectiveness of the drug.

Active ingredients contain:

• Bravecto tablets. The tablets contain fluralaner. The manufacturer guarantees 99% protection against ticks and 100% protection against fleas for twelve weeks. Safe for puppies from 8 weeks of age, for pregnant and lactating bitches. It is safe with a 5-fold overdose. MSD, Austria.
• FrontlineNexgard tablets. Contains afoxolaner. They work for thirty days. According to the manufacturer, they are highly palatable, and with monthly treatment there is no effect of accumulation of the drug in the animal’s body. Manufacturer Merial, France.

An obvious advantage of such treatment is the ability to frequently wash and bathe the animal without the risk of reducing protection.

1. Carbamates.

Manufacturers use the active ingredient propoxur, which is less toxic than the substances of the previous group. Its action is contact, the effectiveness is average, the probability of resistance in fleas and ticks is quite high. According to the reference book pesticides.ru, the repellent properties of propoxur are manifested in a concentration of at least 1%. Acts on fleas, lice, lice and ixodid ticks.

Propoxur is contained in:

• Kiltix for dogs- a combined drug, in addition to propoxur, it contains flumethrin, a substance belonging to the group of perethroids, with more pronounced repellent properties. Manufacturer Bayer, Germany.
• Spray Bolfo for dogs and cats. The downside of this spray is that the manufacturer does not indicate the exact dosage. However, as an additional protection, this spray is widely used and has good reviews. Manufacturer Bayer, Germany.

1. Neonicotinoids.

From this group of insecticides, manufacturers use imidacloprid in the production of flea preparations. It works against fleas, and the mechanism of action of the substance eliminates the emergence of resistance. The action is systemic and contact.

Contains:

• Foresto collar for dogs and cats. A drug that contains active ingredients such as docloprid and flumethrin. The collar is valid for eight months, odorless, and waterproof. Manufacturer Bayer, Germany.
• Advantage drops for cats. A single treatment provides protection against fleas for four weeks. Manufacturer Bayer, Germany.

1. Organophosphorus compounds.

Terachlorvinphos and diazinon are used in the production of insectoacaricides. These substances are easily absorbed through the skin and mucous membranes and are highly toxic. Poorly soluble in water. They act by contact when an insect hits the animal's fur. They do not have repellent properties, but the resistance is quite high for both ticks and fleas. The effectiveness is average. They work against fleas, lice, lice and ixodid ticks.

The most common drugs are:

• Beafar collars for dogs and cats. Contains tetrachlorvinphos. Manufacturer: Beaphar, Netherlands.
• Hartz sprays and collars for dogs and cats. Contains diazinon. Manufacturer Hartz, USA.

1. Amidines

Amitraz belongs to this group of substances. Amitraz is quite toxic and often causes allergic reactions and sedative effects. The action is contact, through the limbs of the insect. Repellent properties are pronounced, and tick resistance to amitraz is unlikely. Dangerous for cats! Does not affect fleas. Effective against ixodid, scabies and demodectic mites.

Amitraz contains:

• Drops Amit. The drug is not used to combat ixodid mites, but is used to treat diseases caused by scabies mites. Manufacturer: Agrovetzashchita, Russian Federation.
• Drops Certificate spot-on for dogs. Manufacturer Merial, France.

It is worth mentioning separately such drugs as drops Lawyer for cats and dogs and Stronghold drops for cats and dogs. These drugs are used in the fight against scabies and demodectic mites, nematodes, and fleas. But none of these drugs works against ixodid ticks.

Active ingredients

Insectoacaricides obtained by chemical synthesis are of industrial importance, although the ability to kill insects was initially noticed in some plants. The most popular chemical compounds used in veterinary medicine:

• phenylpyrazoles (fipronil and pyriprole);
• pyrethroids (permethrin, deltamethrin, etc.);
• isoxazolines (fluralaner and afoxolaner);
• carbamates (propoxur, etc.);
• neonicotinoids (imidacloprid, etc.);
• amidines (amitraz, etc.);
• macrocyclic lactones – avermectins (ivermectin, etc.).

Used less and less due to severe toxicity:

• organochlorine compounds - COCs (DDT, etc.);
• organophosphorus compounds - FOS (chlorophos, thiophos, metaphos, etc.).

OPCs also have a toxic effect on the body, but to a lesser extent compared to COS.

Phenylpyrazoles and pyrethroids are much less toxic and more effective, which explains their popularity as pesticides and insectoacaricides.

Mechanism of action

Insectoacaricides also differ from each other in their mechanism of action.

Disturbs the transmission of nerve impulses:

• interfere with the process of ion exchange in nervous tissue, causing paralysis (pyrethroids);
• block the enzyme cholinesterase (carbamates, FOS);
• are antagonists of nicotinic acetylcholine receptors (imidacloprid);
• block GABA receptors nervous system(phenylpyrazoles, avermectins).

Chitin synthesis inhibitors and juvenoids:

In addition to insectoacaricides, a large practical significance have repellents - substances that repel insects and thus prevent attacks on animals. They can be of natural origin (essential oils of clove, citronella, lavender) or chemical (DEET, IR).

Side effects

Classes of insectoacaricides have varying degrees of toxicity to warm-blooded animals. The most dangerous are COS, FOS and carbamates, with or without overdose correct use may be observed:

• damage to the nervous system,
• hematopoietic disorders,
• toxic and mutagenic effect on the fetus,
• allergic reactions.

Pyrethroids and phenylpyrazoles have relatively high profile safety for people and animals, since they are quickly eliminated from the body without accumulating in tissues.

When treating pets, it is important to follow the dosage of medications. Even with proper use, individual intolerance or local skin reaction is possible.

Abamectin, ivermectin, doramectin and other macrolides are widely used in veterinary medicine due to their high efficiency and slow elimination from the body. They can cause a negative reaction if the dose is exceeded or if animals with increased permeability of the blood barrier are particularly sensitive to these substances.

In case of an undesirable reaction, wash off the drug with soap and water and provide symptomatic assistance.

If you follow the instructions side effects from insectoacaricides are quite rare. Problems arise when substances that are dangerous to your pet are accidentally used. For example, permethrin is used to treat dogs, but highly concentrated preparations with this active ingredient are toxic to cats.

Ivermectin has been used successfully in dogs different breeds, but it is dangerous for collies, shelties, bobtails and their crosses. There are known cases when dosage forms for external use (drops on the withers) were given orally, and pyrethroid concentrates were injected.

To avoid negative consequences You should carefully read the instructions and get advice from a specialist.

Application for animals

The market for veterinary insectoacaricidal drugs is very wide. Possible forms of funds release:

• shampoo;
• drops on the withers (spot-on);
• collar;
• pills;
• spray;
• injections.

Medicines for pets are used taking into account:

• animal type and breed;
• age (many medications are not recommended for puppies and kittens younger than 8–10 weeks);
• body weight, size;
• health status at the time of treatment;
• nature of the disease or threat of infection.

Most drugs have a broad spectrum of action against fleas, lice, lice, cheyletiella, scabies and ixodid mites. It is possible to achieve a complex effect with low toxicity by using a combination of several insectoacaricides with different effects.

For example, drops on the withers for cats and dogs “Bars” contain:

• fipronil,
• diflubenzuron,
• dicarboximide.

Dicarboximide acts as a synergist, weakening the natural resistance of insects and mites to insectoacaricides. This allows you to reduce the concentration of active substances, reducing the risk of adverse reactions.

In the Bars Forte series of drugs for cats and dogs, in addition to fipronil and diflubenzuron, the composition contains essential oil citronella. Thanks to this, the product has repellent activity, repelling not only fleas and ticks, but also mosquitoes.

The protective effect of “Bars” and “Bars Forte” drops on the withers lasts up to 1–2 months. Collars with insectoacaricides can remain effective for up to 4 months. Bars Forte spray protects against insects for up to 1 month after application, and against ixodid ticks for up to 2 weeks.

Insectoacaricides.

Deratization agents.

Plan.

1. General characteristics and classification of insectoacaricides.

2. Organophosphorus compounds.

3. Organochlorine compounds, derivatives of carbamic acids.

4. Sulfur preparations.

5. Preparations of different chemical groups.

6. Deratization agents.

General characteristics and classification of insectoacaricides

Insectoacaricides are preparations of chemical or biological origin intended to combat harmful insects and mites.

Based on their origin, they are divided into: organophosphorus compounds, organochlorine compounds, carbamates, synthetic pyrethroids and drugs of different groups.

Of the total volume of consumed insectoacaricides, FOS accounts for 43%, COS - 17%, carbamates -25%, and other 15%.

Different arthropods, as well as intermediate forms of their development, are unequally sensitive to pharmacological agents. Therefore, in addition to general concept insecticidal influence distinguishes between the following actions:

ovocidal - destruction of insect eggs,

larvicidal - destruction of larvae and caterpillars,

acaricidal - destruction of ticks;

insecticidal – extermination of insects.

Substances that repel insects from animals are called repellents, and insect attractants - attractants.

According to the routes of penetration into the body of insects, they are divided into:

Contact, penetrating the hemolymph through the cuticle of the insect;

Intestinal, entering the insect’s body through the digestive apparatus;

Fumigant, penetrating Breathe-helping machine.

IN last years attention is paid to systemic insecticides. Introduced into the animal's body enterally or parenterally in doses that are harmless to the animal, systemic insecticides destroy the larvae of gadflies migrating in the tissues of the animal.

Requirements for insectoacaricides:

1. Must have a specific effect on arthropods at all stages of development when using minimal doses;

2. Maintain efficiency under different weather conditions;

3. Be economical;

4. Be safe (for staff and animals);

5. Should not have a long-term effect.

Insecticides are used in natural conditions in places where insects accumulate and breed, in rooms and on the body of animals.

They are used by spraying, dusting, bathing animals and aerosol treatment.

Insectoacaricides are used in the form of solutions, emulsions, lotions, suspensions, powders (dusts), aerosols, pur-ons, insecticidal ointments, insecticidal pencils, insecticidal soap, zoo shampoos, films, tags, collars, smoke bombs.

The type of habitat of arthropods and the phase of ontogenesis determine the choice of means of control:

when fighting sarcoptic mites - buying and spraying animals;

with midges and horseflies - aerosol treatments and spraying;

with lice and fleas - insecticidal powders, shampoos, various soaps, etc.

- 2 – Organophosphorus compounds (phos)

Compounds of this group are esters of a number of acids: phosphoric, thiophosphoric, dithiophosphoric, etc.

Advantages of FOS - wide spectrum of insecticidal action, low resistance in objects environment.

FOS are excreted unchanged through the respiratory tract (20 - 25%) and in urine (30%).

OPCs are characterized by the phenomenon of “Lethal synthesis”, when more toxic metabolites are formed from less toxic parent drugs.

Chlorophos (neguwon, dipterex)Сhlorophosum.

White crystalline powder, highly soluble in water and most organic solvents.

Has a detrimental effect on insects and helminths. Used to treat animals against flying insects. Cows are treated after milking. Has high systemic activity. It kills gadfly larvae located in animal tissues, not only when used internally, but also when used externally.

Hypodermin-chlorophos Hypodermini-chlorophosum .

11.6% alcohol-oil solution of chlorophos.

Transparent yellowish liquid with a slight aromatic odor. Used against subcutaneous gadfly larvae by watering large cattle in a dose of 16 ml - for animals weighing up to 200 kg and 24 ml - for larger weights.

DDVF (dichlorvos, dichlorvos) DDVF.

Transparent, colorless or slightly yellow liquid, poorly soluble in water.

Has a selective effect on insects, ticks, helminths. Included in the drug "Estrozol".

Karbofos Carbophosum.

Colorless liquid. Used in the form of 1% aqueous emulsion and 4% dust, “Pedilin” shampoo - to combat lice eggs and larvae, “Carbozol” aerosol.

Diazinon Diazinonum (neocidol, basadine).

In the Republic of Belarus it is produced under the name “Ratsidol”.

Cattle are treated in a ratio of 1:1000, sheep and pigs - 1:2400.

Colorless oily liquid, poorly soluble in water.

Produced in the form of 25 - 60% emulsion concentrate, 40% wettable powder, 5% dust.

Dursban, sulfidophos, phoxim, trichlorometaphos, phthalophos, etc. are also used.

Proteid Proteidum

The drug contains 3% alpha-cypermethrin and 30% chlorfenvinphos, emulsifiers and organic solvents.

Before use, the drug is diluted in a ratio of 1:1000.

Rateid Rateidum

An insectoacaricidal drug, which is a transparent liquid of yellow or light brown color with a specific odor. Contains 5% cypermethrin, 30% chlorfenvinphos, emulsifiers and organic solvents.

The protective residual effect on the skin and hair of animals lasts up to 30 days.

Before use, rateid is mixed with water in a ratio of 1 part of the drug and 1000 parts of water (1: 1000).

1. Insectoacaricides.

2. Deratization agents.

The organism of arthropods is a specific environment where pathogens, in addition to their mechanical presence, can go through phases of their development, accumulating biomass, preparing for a change of host. With their help, pathogens of bacterial infections such as tularemia, brucellosis, listeriosis, leptospirosis, protozoans and helminthiasis are transmitted.

Insectoacaricides are preparations of chemical or biological origin intended to combat harmful insects and mites.

Based on their origin, they are divided into: organophosphorus compounds, organochlorine compounds, carbamates, synthetic pyrethroids and drugs of different groups.

Of the total volume of consumed insectoacaricides, FOS accounts for 43%, COS - 17%, carbamates -25%, and other 15%.

Different arthropods, as well as intermediate forms of their development, are unequally sensitive to pharmacological agents. Therefore, in addition to the general concept of insecticidal influence, the following actions are distinguished:

ovicidal - destruction of insect eggs, larvicidal - destruction of larvae and caterpillars, acaricidal - destruction of mites, pesticide - wide spectrum of action. Substances that repel insects from animals are called repellents, and substances that attract insects are called attractants.

According to the routes of penetration into the body of insects, they are divided into contact ones, penetrating into the hemolymph through the insect cuticle; intestinal, entering the insect’s body through the digestive apparatus, and fumigant, penetrating through the respiratory apparatus. In recent years, attention has been paid to systemic insecticides. Introduced into the animal's body enterally or parenterally in doses that are harmless to the animal, systemic insecticides destroy the larvae of gadflies migrating in the tissues of the animal.

Requirements for insectoacaricides:

1. Have a specific effect on arthropods at all stages of development, and when using minimal doses;

2. Have persistent ability;

3. Maintain efficiency under different weather conditions;

4. Cost-effective;

5. Safety for operating personnel;

6. Should not have a long-term effect.

If several years ago the main indicator limiting their use was their toxicity and persistence in the environment, today the long-term effect of the action comes first: mutagenic, teratogenic, carcinogenic, etc.

The mechanism of action of insecticides is different. Some of them disrupt the chitinous cover of the insect, others change the function of the respiratory or digestive organs. But the most effective is disruption of individual metabolic links after drug resorption.

Insecticides are used in natural conditions in places where insects accumulate and breed, in rooms and on the body of animals.

They are used by spraying, dusting, applying to the surface of the body using purons (watering animals along the spine with compositions of organic solvents and pesticides), bathing animals and aerosol treatment.

Insectoacaricides are used in the form of solutions, emulsions, lotions, suspensions, powders (dusts), aerosols, purons, insecticidal ointments, insecticidal pencils, insecticidal soap, zoo shampoos, films, tags, ear numbers, collars, smoke bombs.

The type of habitat of arthropods and the phase of ontogenesis determine the choice of means of control:

* when fighting sarcaptoid mites - buying and spraying animals;

* with midges and horseflies - checkers, tablets, cords, aerosol preparations;

* with lice and fleas - insecticidal powders, shampoos, various soaps, etc.

Due to the ban on the use of persistent and highly toxic chemical compounds, the sanitary and toxicological significance of these pesticides has significantly decreased, but their danger to living objects of nature is still quite high, which has a detrimental effect on the external environment.

Handling them requires precision, punctuality, correct preparation of working solutions, compliance with the timing and dosage of their use. Particular attention should be paid to maintaining personal hygiene conditions and compliance with these requirements by all livestock workers. The doctor must be well aware of the toxicity of insecticides for animals and, if the very first signs of poisoning appear, quickly apply the appropriate antidote.

Organophosphorus compounds.

Compounds of this group are esters of a number of acids: phosphoric, thiophosphoric, dithiophosphoric.

The advantages of FOS are a wide range of insecticidal action, low resistance in environmental objects.

Two groups: contact and systemic action.

Contact-action drugs include chlorophos, trichlorometaphos-3, karbofos, bytex, metaphos, fusalon, gardon, neocidol, etc.

Systemic drugs include antio, amifos, phosphamide, phospholidone, etc.

Some drugs - phosphamide, antio, have contact and systemic effects.

Under the influence of physical and chemical environmental factors, OPs undergo isomerization and transalkylation, during which more active and toxic compounds are formed. In the body, they undergo oxidative desulfurization (the elimination of sulfur associated with a phosphorus atom and its replacement with oxygen); the formation of conjugates with glucuronic and sulfuric acids, glutamine is possible. FOS are excreted unchanged through the respiratory tract (20 - 25%) and in the urine (30%).

The mechanism of action of FOS on insects and mammals is the same and consists of inhibition of cholinesterase, which leads to excessive accumulation of acetylcholine and disruption of the transmission of nerve impulses, which is expressed by short-term excitation and then paralysis of the nervous system.

In insects, body tremors (mainly limbs), movement coordination disorder with loss of the ability to fly, paralysis, and death are observed.

Chlorophos (neguwon, dipterex)

White crystalline powder, highly soluble in water and most organic solvents.

Has a detrimental effect on insects and helminths. Used to treat animals against flying insects. Cows are treated after milking. Has high systemic activity. It kills gadfly larvae located in animal tissues, not only when used internally, but also when used externally.

Hypodermin - chlorophos

Hypodermini-chlorophosum.

11.6% alcohol-oil solution of chlorophos.

Transparent yellowish liquid with a slight aromatic odor. It is used against the larvae of the subcutaneous gadfly by watering cattle in a dose of 16 ml - for animals weighing up to 200 kg and 24 ml - for animals weighing more than 200 kg.

Dioxaphos
Dioxaphosum.

16% solution of chlorophos in an organic solvent. Dose 12 ml and 16 ml (similar to hypoderminchlorophos).

DDVF (dichlorvos dichlorvos)

Transparent, colorless or slightly yellow liquid, poorly soluble in water.

Has a selective effect on insects, ticks, helminths.

Karbofos

Colorless liquid. Used in the form of 1% aqueous emulsion and 4% dust, “Pedilin” shampoo - to combat lice eggs and larvae, “Carbozol” aerosol.

Diazinon

Diazinonum (neocidol, basadine).

Colorless oily liquid, poorly soluble in water.

Produced in the form of 25 - 60% emulsion concentrate, 40% wettable powder, 5% dust.

Dursban, sulfidophos, phoxim, trichlorometaphos, phthalophos, etc. are also used.

Organochlorine compounds.

Organochlorine compounds are a group of drugs used in agriculture for various purposes. In veterinary practice, chlorinated derivatives of cyclic hydrocarbons are most often used.

Their characteristic feature is high persistence, i.e. resistance to the influence of environmental factors.

These are lipotropic substances.

These are mainly powders, less often liquids, poorly soluble in water, well in organic solvents and oils.

Mechanism of insectoacaricidal action:

easily penetrate the hemolymph and tissue cells, undergo dechlorination with the formation of free radical and peroxide compounds that destroy cellular structures. Just like FOS, they block acetylcholinesterase.

Until recently, HCH was used. Since 1989, its use has been prohibited.

Aurikan

Auricanum. Ear drops (Hungary).

Lightly colored liquid with slight opalescence.

Thanks to its multi-component composition, it is effective against ear diseases in dogs and cats (microbial otitis media, otodectosis).

Place 10 drops in each ear for 7 days.

prednisolone sodium - 0.03 g;

hexamidine isothionate - 0.05 g;

tetracaine hydrochloride - 0.2 g;

lindane (HCCH) - 0.1 g;

xylene 0.5 g;

glycerin - 2 g;

distilled water up to 100 ml.

Gamma isomer of hexachlorocyclohexane (lindane)

Crystalline powder of a whitish-cream color with a specific odor.

Used in combination with creolin.

Folbex (cancer - 338). IN pure form- light yellow crystals. Soluble in alcohol. Used to combat varroosis of bees.

Carbamates.

In terms of biological activity they are very close to FOS; they inhibit cholinesterase.

Their positive property is their relatively rapid decomposition in the external environment.

The following have been used in veterinary practice:

Baygon (proposcur, unden, aprocarb).

White crystalline substance, highly soluble in organic solvents.

An effective remedy fight against mosquitoes, flies, cockroaches and other insects, as well as ticks. It is used against mosquitoes and flies in the form of a 2% aqueous emulsion with a consumption rate of 100 ml/m2.

Release form - 80% and 20% emulsion concentrate, 1% dust and other forms (Bayer company).

Bolfo-powder (1% proposcur) - animals are powdered 2 - 3 times a week;

Bolfo-shampoo - bath for 5 - 10 minutes;

Bolfo collar;

Bolfo-spray (cans), etc.

Sevin

The white powder is insoluble in water, produced in the form of 50 - 80% wettable powder or 7.5% dust.

It is used in the form of 0.5 - 1% suspension, in the form of 2% and 7.5% dusts.

Sulfur preparations.

Sulfur and its compounds are among the most important classes of pesticides. The introduction of sulfur into organic acaricides increases the effectiveness and reduces the toxicity of the drug for warm-blooded animals.

Sulfur as an element has almost no effect on the animal body, but interacting with alkalis and proteins, it turns into active compounds. The skin and digestive tract have all the conditions for the formation of such active compounds. For example, when sulfur is used on the skin, hydrogen sulfide and partially sulfur dioxide are partially formed, which act acaricidal, antiseptic and irritate the exteroceptors of the skin.

Organic sulfur-containing compounds are known to have biologically active properties: thiophenols, sulfides, disulfides. Aromatic disulfides have strong acaricidal properties.

Purified sulfur

Sulfur depuratum.

Lemon-yellow powder.

Used for the treatment of scabies, trichophytosis, dermatitis in the form of 10 - 30% ointments, liniments, dusts. When taken orally, it irritates intestinal interoreceptors, which contributes to the manifestation of a laxative effect. It is also used as an antidote for a number of poisonings.

cattle - 100 - 200 g;

small cattle - 50 - 100 g;

dogs - 10 - 15 g;

pigs - 15 - 25 g.

Sulfur precipitated

Sulfur praecipitatum.

A tiny powder that is easily absorbed when administered orally, which can lead to poisoning. It is applied externally in the form of 5 - 20% ointments.

Sodium thiosulfate

Sodium thiosulfas.

White crystalline powder, highly soluble in water.

When administered intravenously, it has an antitoxic, anti-inflammatory, and antidote effect (for poisoning with cyanides and heavy metals). It is one of the components of the Demyanovich remedy used to treat scabies (first, the affected areas are treated with a 60% sodium thiosulfate solution, after which it dries, a 10% HCl solution is applied).

Unithiol

Release form: powder, tablets of 0.25 and 0.5 g, ampoule 5% solution in ampoules of 5 ml.

The dose for intravenous administration is 10 - 20 mg/kg.

In addition, sulfur and sulfur-lime dust, colloidal sulfur, and colloidal sulfur paste are used.

Plizol (diphenyl sulfide).

Obtained as a by-product in the production of coal-tar phenols.

Homogeneous, dark-colored oily liquid.

It is used as an acaricide for treating sheep in the form of 0.5 - 1% emulsions.

Lepran- a sulfur-containing product of coal tar processing, containing 10 - 14% benzothiophene.

The liquid is dark brown in color with the smell of coal oil.

The drug can be used for anti-scab treatment of pregnant and lactating sheep.

Question 5.

Pyrethrins and pyrethroids.

Pyrethrum is a “Persian” powder, which is one of the best drugs in terms of its speed of action on insects and its harmlessness.

It is obtained from perennial species Dolmatsky and Caucasian chamomile. Active substances of pyrethrum - six close to each other chemical substances: pyrethrin - 1, pyrethrin - 2, cyperin - 1, cyperin - 2, jasmoline - 1, jasmoline - 2, united under one name - pyrethrins.

Currently, analogues of natural compounds are being especially intensively studied - synthetic pyrethroids, the production of which exceeds 3000 tons per year - permethrin, cypermethrin, butox, fenvalerate, etc.

The advantage of pyrethroids is that they have high insecticidal properties, which are explained by an almost instant killing effect; they are harmless to humans and animals, since they are quickly metabolized when they enter the body.

A significant drawback that limits the practical use of many synthetic pyrethroids is their instability in the light and in the presence of atmospheric oxygen.

These are nerve poisons. The death of insects occurs as a result of excessive stimulation of the central and peripheral nervous system (stimulation of sensory, central and motor axons) - their molecules wedge into Na + conducting channels, etc. sodium current increases. Channels cannot return to their original state. As a result, the axon is constantly polarized, which leads to its death as a result of hyperexcitation.

One of the properties that determines their high insecticidal activity is their pronounced lipophilicity, which increases the intake of pyrethrins into the body of insects.

Their insecticidal activity increases with decreasing temperature, and almost disappears at temperatures above 30 o.

Because pyrethroids are used in very low doses, they are the most environmentally friendly and have the least risk of pesticide contamination of livestock products.

Permethrin (ambush, corsair).

Preparative forms:

stomazan - 20% emulsion concentrate;

creopir - a composition of creolin and 2% permethrin or 2% stomasan;

anometrine N - 20% emulsion concentrate;

pyrvol - 2% emulsion of permethrin on dioxanol.

Cypermethrin (cymbush, ripcord, etc.)

Preparative forms:

kinmiks - 25% emulsion concentrate;

creoquine - 2% emulsion of kinmix on creolin;

dust “Tsimtal”;

insecticidal pencils “Iney”, “Nika”, “Virtox”, etc.; aerosols “Tsiperol”, “Tsidem”.

Decamethrin (deltamethrin).

Preparative forms: decis, butox.

Biologically active substances with insectoacaricidal properties.

Avermectins

A complex of eight chemically similar substances, representing a 16-membered macrolide lactone combined with two oleandrose sugar residues. This is a waste product of the Streptomyces avermitilis culture.

Ivermectin - semi-synthetic hydrogenated derivative of abamectin.

Doramectin- a natural fermentation product of Streptomyces avermytilis.

Moxidectin- semi-synthetic derivative of the product formed by Str. cyaneogriseus (does not contain sugar residues).

The following drugs containing ivermectins and avermectins are used:

ivomec 1% injection;

Ivomec 0.5% puron;

duotin (1% abamectin solution);

Baymek 1% injection;

dektomax 1% injection;

aversect 2% injection;

aversectin ointment;

moxidectin 1% injection.

Pharmamedin compounds

Amitraz

White crystalline substance, slightly soluble in water. Metabolized in the body. Inhibits a 2 - adrenergic receptors.

Safe for ruminants, but toxic to horses.

The emulsion concentrate is used for feeding and spraying cattle against ticks and lice at a concentration of 0.02%; for spraying pigs 0.05 - 0.1%; dogs and cats 0.05%.

Its dosage forms:

amitrazine, dekta, ice, etc.

Benzylphenylurea derivative

Program- systemic insecticide.

Release form: tablets (red - 67.8 mg DV; gray - 209.4 mg DV), suspension in capsules (orange - 135 mg DV; green - 270 mg DV).

For cats and dogs orally 2 times with an interval of 30 days:

dogs - 10 mg/kg w. m. (tablets);

cats - 30 mg/kg w. m. (capsules).

Repellents

From the Latin repello - repulse, drive away, substances that repel arthropods from animals and birds.

They are used mainly to protect animals from attacks by blood-sucking insects and to prevent vector-borne diseases.

In modern practice, they are mainly used as R. chemicals long-lasting compounds - ethers and esters, alcohols, aldehydes, amides, essential oils.

There are R. olfactory, or fumigants (volatile substances), which act on the nerve endings of the olfactory organs of arthropods and prevent them from choosing an object of attack (dimethyl phthalate, diethyltoluamide, kuzol, etc.); anti-bite or contact, acting on the taste and olfactory organs of insects upon direct contact with the treated surface (gasoline, indalone, etc.); masking or deodorizing, which neutralize or destroy odors that attract insects (lemon oil).

Most R. belongs to the class of low-toxic compounds for warm-blooded animals, and therefore many of them, for example, benzimine (hexamide), diethyltoluamide (DETA), preparations R - 203, RV - 5, dimethyl phthalate, indalone, kuzol, oxamate are used in veterinary medicine .

The method of low-volume, small-droplet and aerosol treatment is effective, in which the bulk of the R. falls on the animal’s hair, which prevents the absorption of drugs through the skin and reduces the risk of milk contamination. It is prohibited to handle animals with damaged skin integrity. In contact with the mucous membranes of the eyes, nose, and mouth, R. causes irritation.

Attractants

From the Latin attraho - I attract to myself.

Baits, specific substances that attract insects and are used to combat them.

Unlike repellents, insecticides are strictly specific and attract only a certain type of insect.

A. are distinguished: sexual (attract individuals of the opposite sex), food (as a source of nutrition) and A. - a substrate for laying eggs. Highest value have sexual A., secreted by females and related to sex pheromones of insects (BAS that stimulate sexual behavior). For example, sexual A. are isolated from females of gypsy and black American silkworms. Various chemical compounds (ammonium carbonate, phenyl esters, amines, etc.) also have attractive properties.

In the fight against flies and cockroaches we received wide use liquid and dry food A. in combination with insecticides.

Of particular interest are A. in gaseous form. for example, carbon dioxide to attract mosquitoes, midges, ticks, as well as light traps (using UV rays) used to catch mosquitoes, midges, midges in the evening and at night.

A. is used when inspecting an area for pest infestation, as well as for the direct destruction of harmful insects.

An insectoacaricidal agent is described containing as active ingredients a composition of fipronil and alphacypermethrin at their concentration in wt.% in general composition agents: fipronil 0.01-10.0, alphacypermethrin 0.01-10.0, at a ratio mass fractions 1 part fipronil to 0.1-20 parts alphacypermethrin. The invention can be used to combat carriers of various vector-borne and skin infections, to destroy insects in places where domestic animals are kept, and to destroy house dust mites that increase the allergenic load on the body of animals and humans. The product can be used in the form of lotion, solution, spray, drops for topical use, wool conditioner, etc. 7 z.p. files, 1 table.

Prevention of natural focal infections of viral, bacterial, protozoal and rickettsial etiology, the causative agents of which are transmitted by ixodid ticks (tick-borne encephalitis (TBE), borreliosis (IB)), is a problem for public health. Representatives of the families Ixodidae Argasidae, Sarcopnidae and Demodicidae have the greatest epidemiological distribution of animal diseases (pyroplasmosis, borreliosis, otodectosis, demodicosis, sarcoptoidosis, notoedrosis, “plucking itch”). Modern prevention of tick-borne infections is based on nonspecific protection of people and animals from attacks by ticks, carriers of infections, since there are no vaccines against most of these infections. This problem is solved by using acaricidal means for personal protection.

Therefore, an urgent task of modern veterinary medicine and medicine is the development of insect repellent agents that would have the properties of fast, reliable protection against a wide range of insects and ticks, would have low toxicity and a sufficiently long-lasting effect.

To combat insects, mainly compounds related to pyrethroids, organophosphorus preparations, carbamates and heterocyclic derivatives are used. Finished forms of preparations containing one compound as an active substance usually have a relatively narrow spectrum of insecticidal activity, a short time of protective action and lead to rapid development in insect populations resistance to the active substance.

Existing combined insecticidal preparations, along with fairly high efficiency, also have a number of significant disadvantages, because often do not take into account the totality of properties of compounds associated with the mechanism of action, spectrum of action, onset of effect, duration of effect, routes of circulation and excretion from the body, toxicity, stability when used - on the skin on the surface various materials(photostability, enzymatic lability), etc.

There is a known composition for the treatment of arachnoenthomosis, containing fipronil and esfenvalerate as active ingredients (RF patent 2181243, 2002). The disadvantages of the composition are the limited range of applications - for the treatment of arachnoenthomosis in animals and the inactivity of esfenvalerate against taiga ticks. There is a possible effect of temporarily increasing the aggressiveness of ticks due to esfenvalerate, which increases the risk of bites and accelerates the suction of ticks at the initial moment it comes into contact with the skin of an animal or person.

An insectoacaricidal composition for mammals is known, containing fipronil and benzyl benzoate as active ingredients (RF patent 2283590, 2006). However, benzyl benzoate and fipronil do not have a quick contact effect; they are acceptable only for products with long-term application and with the possibility of long-term contact with insects for manifestation sufficient insectoacaricidal activity.

An acaricidal agent is known containing as an active substance a mixture of alphacypermethrin and didecyldimethylammonium bromide. In this case, alphacypermethrin is used in an amount of 0.01-0.15% (RF patent 2242967, 2004). The disadvantage of this product is the use in this composition of a quaternary ammonium compound (QAC) - didecyldimethylammonium bromide, which acts as an antimicrobial and disinfectant, but does not have a significant effect on prolonging the effect or expanding the range of acaricidal activity of the product. This combination allows you to expand the indications for use of the product due to the combination of insecticidal and disinfectant properties of the components, but does not change the insecticidal characteristics of the product.

An acaricidal agent is also known, including imiprotrin and alphacypermethrin (RF patent 2280983, 2006). The disadvantages of this product are that both components are characterized by a rapid knockout effect, but they do not have a sufficient duration of insecticidal action due to the specificity of penetration and distribution in the animal’s body. Therefore, this combination will be effective for treating surfaces to protect primarily from cockroaches, ants, etc. due to the rapid contact action, but it will not be effective enough to provide a prolonged insectoacaricidal effect when applied directly to the skin and/or fur of an animal.

The proposed insectoacaricidal agent is devoid of the disadvantages inherent in known combination agents due to the fact that it contains as active ingredients a composition of fipronil and alphacypermethrin at their concentration in wt.% in the total composition of the product:

In this case, the ratio of the mass fractions of fipronil and alphacypermethrin, depending on the form of the drug, can vary from 1 to 0.1 to 1 to 20, respectively.

The pyrethroid alphacypermethrin is a mixture of two enantiomers (1R) - cis - S and (1S) - cis - R in a 1:1 ratio. It has high acaricidal activity, a rapid onset of action, sharply limits the movement of ticks on the surface, and does not accelerate the suction of ticks to the animal.

The disadvantages of alphacypermethrin are: destruction under the influence of UV sun (photolability), relatively high toxicity to animals, irritation, deep penetration through the skin, moderate persistence and excretion from the body not only through skin and hair, i.e. relatively rapid decline in external tissue concentrations and reduced contact exposure.

When applied to the skin, fipronil is localized in the sebaceous glands without entering the animal’s blood. Thus, a “reservoir” effect is created, which ensures long-lasting action and preservation of effectiveness when bathing an animal using shampoo. With sebum, fipronil spreads over the surface of the skin and coat. Long lasting effect sunlight the drug applied to walls, materials or animals does not reduce the effectiveness of the drug.

The invention uses a composition of substances with a fast (immediate) and slower (delayed) acaricidal and insecticidal lethal effect.

The use of fipronil, which is superior to alfacypermethrin in terms of duration of effect and is characterized as a less toxic (less irritating) compound for humans and animals, reduces the overall toxicity of the composition of fipronil and alfacypermethrin while maintaining activity and effectiveness. Fipronil and alphacypermethrin complement each other in other indicators that are important for practical use for guard various types animals, when used in different seasons, provide a synergistic effect and increase the versatility of the insectoacaricidal activity of the composition.

Table 1 presents the results of studying the properties of solutions of individual substances fipronil and alphacypermethrin in comparison with their composition in relation to adult forms of ixodes ticks (Ixodes persulcatus and Ixodes ricinus).

Developed ready-made forms of insectoacaricidal agent, based on the use of a combination of fipronil and alfacypermethrin, provide more reliable protection of animals and people from tick attacks than single agents of these substances, repellent agents and comparable known analogues.

One of the ready-made forms of an insectoacaricidal agent is drops for topical use (drip application to the skin, for example, on the withers of an animal), intended for long-term protection of animals from ticks and insects (from 2 weeks or more). The drops contain fipronil in a wt.% concentration of at least 0.5% (preferably 7%) and alphacypermethrin in a wt.% concentration of at least 0.25% (preferably 1.0%).

The finished form in the form of a lotion, solution, spray for application to the fur, skin, plumage of birds has an insect-repellent effect with a repellent effect for at least 3 hours and an insectoacaricidal effect for at least 1 week and contains fipronil in a wt.% concentration of not more than 1% (preferably 0.1%) and alphacypermethrin in a concentration by weight of not more than 1% (preferably 0.1%). Additionally, this form contains repellents, such as acrep and/or DEET, with a total mass fraction of repellents of at least 5%.

This form of the product is used by aerosol propellant or non-propellant spraying or direct application with a napkin, mitten, etc., to provide an insect-repellent effect in order to protect animals from attacks by insects and ticks in the spring-autumn period when walking in the forest, etc. etc., for targeted local application for the purpose of direct destruction of attached (ticks) or insects. It can also be used as an external treatment for dressings to protect wounds from flies.

Liquid form (solution, lotion, emulsion) for use as a spray for treating animal housing with an effect duration of at least 1 week (10-14 days) contains fipronil in a wt.% concentration of not more than 1% (preferably 0.1%) and alphacypermethrin in a concentration by weight of not more than 1% (preferably 0.3%).

This form of the product is used to treat curtains, mosquito nets, walls, bedding, etc. in conditions of tourism, fishing, hunting and work, on vacation, on farms, in stables, in enclosures, in other utility and residential premises, at competitions with a high number and activity of blood-sucking insects and ticks; to protect against insects spread by rodents.

Each of the listed forms may additionally contain as an active component benzyl benzoate in a working concentration wt.% of at least 0.1% (preferably 1%) and/or melia extract (Mélia azedárach L.) in a concentration wt.% of at least 0.1 % (preferably 0.5%). It is also possible to add fir essential oil and/or vanillin for aromatization, deodorization and enhancing the repellent effect.

Each of the listed forms (preferably a composition for topical use) can be used for inclusion in a collar made from polymeric, natural or combined materials. When wearing a collar, animals are provided with a protective insectoacaricidal effect.

The finished form in the form of a wool conditioner in the form of a balm or spray combines a short acaricidal effect (2-3 days) with cosmetic and hygienic properties: it provides effective dry cleaning of wool (improving combing, reducing hair tangles, combing and mechanical removal insects), antifungal effect, reducing dandruff formation. The balm contains fipronil in a concentration by weight of not more than 0.1% (preferably 0.02%) and alphacypermethrin in a concentration by weight of not more than 0.1% (preferably 0.02%) and additionally contains the active ingredients - benzyl benzoate in a concentration of wt.% not more than 1% and melia extract (Мélia azedárach L.) in a concentration wt.% not more than 1%. Conditioning additives, such as cellulose and silicone derivatives, are used as additional auxiliary components that ensure easy combing of wool and other cosmetic and hygienic effects.

The product can be produced as a concentrate in liquid form, which is diluted to recommended working concentrations before use. The content of fipronil in the concentrate is up to 5% (preferably 1%), alphacypermethrin - up to 10% (preferably 5%). The content of benzyl benzoate in the concentrate can be up to 10%, melia extract - up to 3%.

Before use, the concentrate is diluted 20-30 times in water and applied by aerosol or other method of application to the surfaces to be treated.

Acaricidal drops (composition for topical use)

Recipe

Auxiliary components up to 100 ml: PEG 400, ethyl alcohol, isopropyl alcohol, antioxidant, PEG 40 hydrogenated castor oil, lavender essential oil.

Result

The drug provided insectoacaricidal protection against tick attacks for at least 40 days, and against fleas for at least 60 days.

Insect repellent spray

Recipe

Auxiliary components up to 100 ml: PEG 400, ethyl alcohol, isopropyl alcohol, antioxidant, povidone, PEG 40 hydrogenated castor oil, lavender essential oil.

Purpose and method of use

The product was used in a propellant-free package with a spray nozzle for applying the drug as a spray. The bottle is held vertically, directing the spray from a distance of 10-25 cm against the growth of the fur (raising long hair), if necessary, treat the animal's equipment and clothing (clothing, etc.). Treatment is carried out before a walk in places with a high risk of insect attacks (especially ticks) at the rate: for cats and dogs - 2-3 ml per kg of weight, for horses 60-120 ml per full processing. During processing, it was taken into account that one press of the spray device corresponds to 0.7 ml of the drug. It is necessary to avoid contact with eyes, mucous membranes, and open wounds, so the product should be distributed in these places with great care, for example, using a napkin or sponge.

Result

The repellent effect was formed immediately and persisted on wool for up to 8 hours, on fabrics for up to 5 days. The product provided acaricidal protection for at least 10 days.

When applied to a wound dressing (aerosolized until the bandage was lightly wetted), the drug provided protection against flies for at least 6 hours.

Insectoacaricidal solution for treating animal housing

Recipe

Auxiliary components up to 100 ml: PEG 400, ethyl alcohol, isopropyl alcohol, antioxidant, povidone, PEG 40 hydrogenated castor oil, lavender essential oil, denatured alcohol (bitrex).

Purpose and method of use

The product was used in a propellant-free package with a spray nozzle for applying the drug as a spray. The bottle is held vertically, directing the spray from a distance of 20-30 cm onto the surfaces to be treated (floor, walls, bedding, stall, enclosure, kennel, etc.).

Result

The drug provided protection against spread and attacks various insects and ticks in places where animals are kept for at least 2 weeks.

Insectoacaricidal concentrate for preparing a solution for treating animal housing

Recipe

Auxiliary components up to 100 ml: PEG 400, ethyl alcohol, isopropyl alcohol, antioxidant, PEG 40 hydrogenated castor oil, lavender essential oil, denatured alcohol (bitrex).

Purpose and method of application

The drug is used to treat places where animals are kept to protect against flying and non-flying insects (mosquitoes, midges, biting midges, flies, gadflies) and ticks.

Used for treating curtains, mosquito nets, walls, ceilings, canopies, bedding, ammunition, etc. on farms, in stables, in enclosures, at competitions, in conditions of tourism, fishing, hunting and under stress, on vacation, with a high number and activity of insects and ticks. Destroys arthropods, prevents their reproduction and spread through carriers - rats, etc.

Before use, the concentrate is diluted 20-30 times with water (0.5 liters of concentrate per 1-1.5 buckets of water). The degree of dilution (20-30) depends on the activity of insects and mites. Mixing is carried out in a clean container by introducing the concentrate into water with constant stirring. Store diluted before use for no more than 10 hours; stir vigorously before application.

Contains bitterness (bitrex) to protect treated surfaces from licking and chewing by animals.

The diluted product is applied by aerosol (using any device for aerosolizing liquids) onto the surfaces to be treated or applied using napkins.

Treatment is carried out at the rate of 10-20 ml of diluted product per 1 m 2.

Consumption: 1 bottle of 0.5 liters is diluted into 1-1.5 buckets, which is enough to treat from 500 m2 to 1.5 thousand m2.

Result

The duration of the insectoacaricidal effect is at least 10 days.

Wool conditioner with insectoacaricidal effect

Recipe

Auxiliary components up to 100 ml: ethyl alcohol, isopropyl alcohol, PEG 400, water, polyquartenium-10, DC 5330, antioxidant, PEG 40 hydrogenated castor oil, lavender essential oil.

Purpose and method of use

The product combines insectoacaricidal properties with cosmetic and hygienic characteristics. Used for dry cleaning of wool - combing improves, hair tangles are reduced, combing and mechanical removal of insects are facilitated. The product was used in packaging on a propellant-free basis with a spray nozzle for applying the drug in the form of a spray. The bottle is held vertically, directing the spray from a distance of 10-25 cm against the growth of the coat, lifting the long coat. Treatment is carried out before the animal walks at the following rate: for cats and dogs - 2-3 ml per kg of weight.

Result

The drug provided insectoacaricidal protection against tick attacks for at least 3 days. The drug makes it easier to comb hair and mechanically remove mites after walking. In addition, when using the drug, a decrease in the formation of dandruff was noted.

Collar with insecticidal effect

Recipe

It is a polyvinyl chloride tape impregnated with an insectoacaricidal composition corresponding in composition to the composition for topical use, at the rate of 0.7-0.8 g of active substance per 10 g of tape. The collar is packaged in a hermetically sealed bag, enclosed in individual consumer packaging.

Purpose and method of use

Used for long-term protection against fleas and ticks.

Place a collar on the neck of an animal (dog, cat) at least 24 hours before going to places where there is a potential for tick attacks. Before walking in areas with large concentrations of ticks, additionally treat the animal’s limbs with a spray. To increase the effectiveness of protection against ticks, the use of a collar is optimally combined with other forms of the drug for a similar purpose in the form of drops or spray.

Result

The active components included in the collar, gradually released from the surface of the tape, are transferred to the animal’s hair and have an insectoacaricidal effect on insects and ticks. As a result, the collar provided protection against fleas for 3 months, against ticks for 1.5 months,

All products from the given examples, if the recommendations for use are followed, do not have a local irritant, skin-resorptive or sensitizing effect.

In all of the above cases, the proposed combination of insectoacaricidal components provides:

Synergistic effect, manifested in increasing the effectiveness of insectoacaricidal action in comparison with monocomponent agents,

Expansion of indications for use,

Acceleration of the onset and prolongation of insectoacaricidal action in comparison with monopreparations.

The addition of repellents to the composition of ready-made forms of the product increases their acaricidal effectiveness and determines the presence of a protective effect against blood-sucking flying insects.

CLAIM

1. An insectoacaricidal agent containing as active ingredients a composition of fipronil and alphacypermethrin at their concentration in wt.% in the total composition of the product:

at a ratio of mass fractions of 1 part fipronil to 0.1-20 parts alphacypermethrin.

2. The product according to claim 1, characterized in that it is a ready-made form in the form of drops for topical use and contains fipronil in a concentration of 2.5-10 wt.% and alphacypermethrin in a concentration of 0.25-2.5 wt.%.

3. The product according to claim 1, characterized in that it is a finished form in the form of a lotion, solution or spray for application to the wool, skin, plumage of birds and contains fipronil in a concentration of 0.05-1.0 wt.% and alphacypermethrin in concentration of 0.01-1.0 wt.% and additionally contains repellents in a concentration of 5 wt.% or more.

4. The product according to claim 1, characterized in that it is a ready-made form in the form of a solution, lotion or emulsion for treating animal housing and contains 0.05-1.0 wt.% fipronil and 0.05-1.0 wt. .%. alphacypermethrin.

5. The product according to any one of claims 2-4, characterized in that it additionally contains benzyl benzoate in a concentration of 0.1-1.0 wt.% and/or melia extract (Melia azedarach L.) in a concentration of 0.1-1, 0 wt.%.

6. The product according to claim 1, which is a finished form of wool conditioner in the form of a balm or spray, characterized in that it contains fipronil in a concentration of 0.01-0.1 wt.%, alphacypermethrin in a concentration of 0.01-0.1 wt.% and may additionally contain benzyl benzoate in a concentration of not more than 1 wt.% and melia extract (Melia azedarach L.) in a concentration of not more than 1 wt.%.

7. The product according to claim 1, characterized in that it is a concentrate in liquid form, which contains, wt.%:

8. The product according to claim 1, characterized in that it is used as part of a collar made of polymer, natural or combined materials.